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DISC1 Regulates the Proliferation and Migration of Mouse Neural Stem/Progenitor Cells through Pax5, Sox2, Dll1 and Neurog2.
Wu Q, Tang W, Luo Z, Li Y, Shu Y, Yue Z, Xiao B, Feng L. Wu Q, et al. Front Cell Neurosci. 2017 Aug 29;11:261. doi: 10.3389/fncel.2017.00261. eCollection 2017. Front Cell Neurosci. 2017. PMID: 28900388 Free PMC article.
Paired box gene 5 (Pax5), sex determining region Y-box 2 (Sox2), delta-like1 (Dll1) and Neurogenin2 (Neurog2) emerged as candidate molecules downstream of DISC1, and rescue experiments demonstrated that increased or decreased expression of either molecule regulated …
Paired box gene 5 (Pax5), sex determining region Y-box 2 (Sox2), delta-like1 (Dll1) and Neurogenin2 (Neurog2) emerged as candi …
Loss of Pax6 Causes Regional Changes in Dll1 Expression in Developing Cerebral Cortex.
Dorà E, Price DJ, Mason JO. Dorà E, et al. Front Cell Neurosci. 2019 Mar 6;13:78. doi: 10.3389/fncel.2019.00078. eCollection 2019. Front Cell Neurosci. 2019. PMID: 30894800 Free PMC article.
The proneural transcription factor Neurog2 is a target of Pax6 that can activate Dll1 expression and we found clear co-expression of Neurog2 and Dll1 in radial glial progenitors, suggesting that Pax6's effect on Dll1 could be mediated through …
The proneural transcription factor Neurog2 is a target of Pax6 that can activate Dll1 expression and we found clear co-express …
Sustained vs. oscillating expressions of Ngn2, Dll1 and Hes1: a model of neural differentiation of embryonic telencephalon.
Barton A, Fendrik AJ. Barton A, et al. J Theor Biol. 2013 Jul 7;328:1-8. doi: 10.1016/j.jtbi.2013.03.004. Epub 2013 Mar 15. J Theor Biol. 2013. PMID: 23499991
Neural progenitor cells show oscillatory expression of the Notch ligand Delta-like1 (Dll1), the Notch target Hes1 and the proneural gene Neurogenin 2 (Ngn2) during embryonic development of the mammalian telencephalon. ...Moreover, when Delta-Notch coupling is canceled, bot …
Neural progenitor cells show oscillatory expression of the Notch ligand Delta-like1 (Dll1), the Notch target Hes1 and the proneural g …
A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis.
Han S, Dennis DJ, Balakrishnan A, Dixit R, Britz O, Zinyk D, Touahri Y, Olender T, Brand M, Guillemot F, Kurrasch D, Schuurmans C. Han S, et al. Development. 2018 Oct 1;145(19):dev157719. doi: 10.1242/dev.157719. Development. 2018. PMID: 30201687 Free PMC article.
Here, we investigated how the highly related proneural genes Neurog1 and Neurog2 interact to control the timing of neocortical neurogenesis. ...Instead, Neurog1(-/-) progenitors preferentially generate neurons, a phenotype restricted to the Neurog2(+) progenitor poo …
Here, we investigated how the highly related proneural genes Neurog1 and Neurog2 interact to control the timing of neocortical neurog …
Oscillations in notch signaling regulate maintenance of neural progenitors.
Shimojo H, Ohtsuka T, Kageyama R. Shimojo H, et al. Neuron. 2008 Apr 10;58(1):52-64. doi: 10.1016/j.neuron.2008.02.014. Neuron. 2008. PMID: 18400163 Free article.
Surprisingly, the proneural gene Neurogenin2 (Ngn2) and the Notch ligand Delta-like1 (Dll1) are also expressed in an oscillatory manner by neural progenitors, and inhibition of Notch signaling, a condition known to induce neuronal differentiation, leads to downregulation o …
Surprisingly, the proneural gene Neurogenin2 (Ngn2) and the Notch ligand Delta-like1 (Dll1) are also expressed in an oscillatory mann …
Differentiation of stem cells derived from carious teeth into dopaminergic-like cells.
Gnanasegaran N, Govindasamy V, Abu Kasim NH. Gnanasegaran N, et al. Int Endod J. 2016 Oct;49(10):937-49. doi: 10.1111/iej.12545. Epub 2015 Oct 3. Int Endod J. 2016. PMID: 26354006
Amongst the notable genes were those from the transcription factors family (FLNA, MEF2C, NEUROG2), signalling pathway family (DLL1, Notch1, TGF-beta1), neuro-inducer family (BDNF) and cell communication family (APBB1). ...
Amongst the notable genes were those from the transcription factors family (FLNA, MEF2C, NEUROG2), signalling pathway family (DLL1